Principles of Virus pandemics – obtained lesions in different levels of structure and function in COVID 19 pandemics in Germany, 2020-2022
Keywords:COVID pandemics, Federal Republic of Germany, Shannon entropy, structural (MST) entropy, incidence, death rate
AbstractAims: To describe and to analyze structure and function lesions induced by COVID-19 pandemics in Germany (2020 – 2022) at different involved level. Material and Methods: The officially published number of infected persons, incidence and number of corona – associated deaths in the Federal Republic of Germany during the period 2020 – January 2022 underwent thorough verification and during the period February 28, 2020 – March 15, 2021detailed computation in relation to the involved public health center, and consistency of data. Shannon entropy and structural (MST) entropy were derived from these data and associated with the health center’s location, covered population and week of publication. Python programs and self - written programs based upon DIAS (Digital Image Analysis Software (1)) served for information analysis of the COVID pandemics. These data display with the damages of social structures and behavior (function) such as demonstrations, violence, overload of public health services and commercial deficits. The next lower level includes artificial aspiration, pulmonary dysfunction, severe lung edema, and damages of the air-blood barrier which contribute to malfunction (individual death) of infected persons. The lowest level describes the adhesion, implementation and spread of virus particles (infection of airways), and the consecutives in behavior and damage of exposed societies. Virtual slides (VS) at microscopic level are used to demonstrate the most significant post mortal anatomic findings. Results: A total of 2,444,615 infected persons were included in the computation, and 70,104 persons died because of or in association with the infection. Distance analysis between the different health centers revealed a time delay of 10 weeks of potential virus jump between the centers. The ‘hot spots’ of the pandemics were associated with the distance of the health centers from the republic boundaries to its neighboring countries. No association of spread velocity and death rate was found with the size of the health centers’ community and their environment (big cities, rural towns, etc.). The lowest level of structure alterations includes virus load associated increased mucus production and dysfunction of ciliated cells in the air conducting system and vital damages of alveolar lining cells (pneumocytes). The activated pulmonary defense system destroys and occludes the pulmonary capillaries. The blocked essential air exchange induces a lethal and often irreversible lung edema. The cause of pandemic associated deaths can only be definitely evaluated from autopsy and not from the officially published mortality data. A complete pulmonary failure is rather rare, in contrast to cardiac malfunction induced by age – related burden of pre-existent pulmonary damages. Interpretation: The well-known COVID pandemics infectious spread conditions namely distance between ‘spreaders’ and potential (non-immunized) ‘receivers’ as well as Virus particle density and transmission conditions correspond to essential life conditions of human societies in general (2-8). Communication and transportation (mobility) are essential conditions of modern societies. Their modifications, limitations or shut down severely violates next higher order structures such as supply, mobility or labor of populations (9-13). This ‘level of orders’ effect can, in addition, exemplarily noted in high incidence and the accelerated Virus spread at the country’s borders. Basic laws of kinetics predict citizen resistance including break outs of violence and intensive protests. They are independent from the political system and, in general cannot be avoided (14-19). The presented model of different ‘affected orders of life structures’ by virus pandemics can explain the difficulties which democratically or otherwise organized societies are confronted to successfully protect their populations.
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